Preclinical safety assessment and pharmacokinetics of gadodiamide injection, a new magnetic resonance imaging contrast agent.

@article{Harpur1993PreclinicalSA,
  title={Preclinical safety assessment and pharmacokinetics of gadodiamide injection, a new magnetic resonance imaging contrast agent.},
  author={Ernest S. Harpur and Dilip Worah and Petter Arnt Hals and E. Holtz and Kazuhisa Furuhama and Hiromichi Nomura},
  journal={Investigative radiology},
  year={1993},
  volume={28 Suppl 1},
  pages={S28-43}
}
In a wide range of preclinical studies of gadodiamide injection (Omniscan, Sanofi Winthrop, New York, NY, and Nycomed AS, Oslo, Norway), the pharmacokinetics of the compound have been delineated and its safety demonstrated. The pharmacokinetic behavior of gadodiamide was consistent with its extracellular distribution. Its half-life in rats, rabbits, and… CONTINUE READING