Preclinical results of sirolimus treatment in transplant models.

@article{Stepkowski2003PreclinicalRO,
  title={Preclinical results of sirolimus treatment in transplant models.},
  author={Stanislaw M. Stepkowski},
  journal={Transplantation proceedings},
  year={2003},
  volume={35 3 Suppl},
  pages={219S-226S}
}
Sirolimus (SRL; rapamycin) is a macrolide antibiotic, which modest anticandidal and tumoricidal activities were superseded by its immunosuppressive potential to block allograft rejection. The most intriguing biological characteristic of SRL emerged after demonstration of its potent synergism with cyclosporine (CsA). Naïve T cells, residing in the G(0) phase of the cell cycle, become activated by three signals. Signal 1 (T cell antigen receptor/alloantigen) and Signal 2 (CD28/B7) progress T cell… CONTINUE READING

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