Preclinical pharmacology of zoledronic acid.

  title={Preclinical pharmacology of zoledronic acid.},
  author={Jonathan R B Green},
  journal={Seminars in oncology},
  volume={29 6 Suppl 21},
The evolution of bisphosphonates over the past 30 years has led to the development of nitrogen-containing bisphosphonates with ever-increasing potency. Recent studies have begun to shed light on the unique mechanism of action and pharmacologic properties of these compounds. On the basis of in vitro studies and animal models of osteoclast-mediated bone resorption, zoledronic acid is the most potent bisphosphonate among a large number of compounds tested, including pamidronate and most other… CONTINUE READING
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