Preclinical pharmacology of the anthrapyrazole analog oxantrazole (NSC-349174, Piroxantrone)

Abstract

Oxantrazole (now designated as piroxantrone) is an anthrapyrazole analog under evaluation as a potentially useful anthracycline-like antitumor agent. In preparation for phase I clinical trials, we characterized certain aspects of oxantrazole preclinical pharmacology, including plasma stability, murine pharmacokinetics, in vitro/in vivo metabolism, and DNA… (More)
DOI: 10.1007/BF00451644

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