Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist

@article{Eden1991PreclinicalPO,
  title={Preclinical pharmacology of ropinirole (SK\&F 101468-A) a novel dopamine D2 agonist},
  author={Rebecca Eden and Brenda Costall and Annette M. Domeney and Philip A. Gerrard and Carol A. Harvey and M. Elizabeth Kelly and Robert J. Naylor and David A. A. Owen and A Wright},
  journal={Pharmacology Biochemistry and Behavior},
  year={1991},
  volume={38},
  pages={147-154}
}

Anxiolytic profile of ropinirole in the rat, mouse and common marmoset

TLDR
Ropinirole did not compromise the effect of amitriptyline in the Porsolt test of depression and in itself produced antidepressant-like effects and may predict an action of ropinirole in man that would provide a superior profile of action over other presently available anti-parkinsonian agents.

S32504, a Novel Naphtoxazine Agonist at Dopamine D3/D2 Receptors: II. Actions in Rodent, Primate, and Cellular Models of Antiparkinsonian Activity in Comparison to Ropinirole

TLDR
S32504 displays potent and stereospecific activity in rodent, primate, and cellular models of antiparkinsonian properties and engagement of D3 receptors contributes to its neuroprotective properties.

D(2), but not D(1) dopamine receptor agonists potentiate cannabinoid-induced sedation in nonhuman primates.

TLDR
Modulation of D(2) dopamine receptor activity by a nonsedating dose of a cannabinoid agonist has implications for the pathophysiology and treatment of dopamine-related neuropsychiatric disorders and drug addiction.

The Effects of a Selective Dopamine D2 Receptor Agonist on Behavioral and Pathological Outcome in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Squirrel Monkeys

TLDR
Results suggest that sumanirole can exert antiparkinsonian effects similar to l-DOPA without the behavioral and morphological consequences of the latter.

S32504, a Novel Naphtoxazine Agonist at Dopamine D3/D2 Receptors: I. Cellular, Electrophysiological, and Neurochemical Profile in Comparison with Ropinirole

TLDR
D3/D2 agonist and antiparkinsonian agent ropinirole mimicked the profile of S32504, which is a potent and selective agonist at dopamine D3 and D2 receptors.

Ligands for the dopamine D 2-like receptors

TLDR
This study synthesized a series of substituted N-(1-benzyl-piperidin-4-yl)benzamides with varying degrees of DA D4 selectivity, and tested four of these benzamides for their ability to inhibit Damphetamine-induced hyperactivity in the rat.
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