Preclinical pharmacology of milnacipran

@article{Briley1996PreclinicalPO,
  title={Preclinical pharmacology of milnacipran},
  author={Michael S. Briley and Jean-François Prost and Chantal Moret},
  journal={International Clinical Psychopharmacology},
  year={1996},
  volume={11},
  pages={9–14}
}
Milnacipran (Ixel) is a new antidepressant which has been developed for its selective inhibition of both serotonin and noradrenaline reuptake and its lack of affinity for neurotransmitter receptors. It inhibits virtually equipotently the reuptake of serotonin and noradrenaline both in vitro and in vivo, as demonstrated by the antagonism of centrally acting monoamine displacers. It has no effect on dopamine reuptake. In addition, milnacipran has been shown by intracerebral microdialysis to… 
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    International journal of psychiatry in clinical practice
  • 2006
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In the treatment of depression, SNRIs appear to have similar effectiveness and when compared to selective 5-HT reuptake inhibitors, they generally exert a superior antidepressant effect, suggesting that individual patients not responding to a SNRI may present a favourable response to another agent within that family.
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