Preclinical pharmacology of GW280430A (AV430A) in the rhesus monkey and in the cat: a comparison with mivacurium.

@article{Savarese2004PreclinicalPO,
  title={Preclinical pharmacology of GW280430A (AV430A) in the rhesus monkey and in the cat: a comparison with mivacurium.},
  author={John J Savarese and Matthew R Belmont and Mir A. Hashim and Robert A. Mook and Eric E Boros and Vicente A Samano and Sanjay S. Patel and Paul L. Feldman and Jan-Ake I Schultz and Michael J. McNulty and Timothy D Spitzer and Douglas L. Cohn and Philip I. Morgan and William B Wastila},
  journal={Anesthesiology},
  year={2004},
  volume={100 4},
  pages={835-45}
}
BACKGROUND No replacement for succinylcholine is yet available. GW280430A (AV430A) is a representative of a new class of nondepolarizing neuromuscular blocking drugs called asymmetric mixed-onium chlorofumarates. It undergoes rapid degradation in plasma by chemical hydrolysis and inactivation by cysteine adduction, resulting in a very short duration of… CONTINUE READING