Preclinical pharmacology of CP-424,391, and orally active pyrazolinone-piperidine growth hormone secretagogue

@article{Pan2007PreclinicalPO,
  title={Preclinical pharmacology of CP-424,391, and orally active pyrazolinone-piperidine growth hormone secretagogue},
  author={Lydia C. Pan and Philip Albert Groton Carpino and Bruce A. Lefker and John A. Ragan and Steven M. Toler and John C. Pettersen and David O. Nettleton and Oicheng Ng and Christine M. Pirie and Kristin L Chidsey-Frink and Bihong Lu and David F. Nickerson and David A. Tess and Michelle A Mullins and David B. Maclean and Paul A DaSilva-Jardine and David Duane Thompson},
  journal={Endocrine},
  year={2007},
  volume={14},
  pages={121-132}
}
Growth hormone secretagogues (GHSs) represent attractive therapeutic alternatives to recombinant growth hormone (GH), given their ability to amplify pulsatile hormone secretion in a relatively physiologic manner. CP-424,391 (391) is a novel, orally active pyrazolinone-piperidine GHS. In rat pituitary cell cultures, 391 stimulated GH release with an EC50=3 nM. The addition of 391 to rat pituitary cells activated intracellular calcium signaling but did not elevate intracellular cyclic adenosine… 
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