Preclinical pharmacology of B-20991, a 5-HT1A receptor agonist with anxiolytic activity.

Abstract

The purpose of this study was to characterize the pharmacological effects of 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1,3-dioxoperhydro imidazo[1,5-a]pyridine (B-20991) by using several biochemical and behavioral assays. Results of binding studies showed that B-20991 binds with high affinity to the 5-HT1A receptor (Ki = 31.7 +/- 1.7 nM), moderate… (More)

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@article{Beneytez1998PreclinicalPO, title={Preclinical pharmacology of B-20991, a 5-HT1A receptor agonist with anxiolytic activity.}, author={M E Beneytez and Mar{\'i}a Luz L{\'o}pez Rodr{\'i}guez and Mar{\'i}a Luisa Rosado and Mar{\'i}a Jos{\'e} Morcillo and Luis M. Orensanz and Jaime A Fuentes and Jorge Manzanares}, journal={European journal of pharmacology}, year={1998}, volume={344 2-3}, pages={127-35} }