Corpus ID: 6493489

Preclinical pharmacologic investigations on a new group of acridine derivatives with oncostatic activity. I. Acute and subchronic action.

@article{Gieldanowski1980PreclinicalPI,
  title={Preclinical pharmacologic investigations on a new group of acridine derivatives with oncostatic activity. I. Acute and subchronic action.},
  author={J. Gieldanowski and Z. Wieczorek and S. Kowalczyk-Bronisz and D. Kowalewska and B. Błaszczyk and G. Skibinski and M. Zimecki},
  journal={Archivum immunologiae et therapiae experimentalis},
  year={1980},
  volume={28 5},
  pages={
          735-54
        }
}
The influence of l-nitro-9-/2-dihydroxyethylamino-ethylamino-/-acridine (C-835) and l-nitro-9/3-izopropylaminopropylamino/-acridine (C-846) on the basic functions of animal organism in acute and subchronic experiments was studied. Both compounds displayed distinct all-biologic activity. Their toxicity (LD50) in mice was contained in milligramme interval (i.v.), while LD50 administered into the stomach was several dozen times higher. Even administration in protective phosphate buffer, which… Expand