Preclinical pharmacokinetics of the radiomitigator KZ-41 in rats

@article{Zeng2011PreclinicalPO,
  title={Preclinical pharmacokinetics of the radiomitigator KZ-41 in rats},
  author={Kui Zeng and K. Thompson and C. Presley and D. Miller and C. Yates},
  journal={Xenobiotica},
  year={2011},
  volume={41},
  pages={1006 - 1012}
}
  • Kui Zeng, K. Thompson, +2 authors C. Yates
  • Published 2011
  • Chemistry, Medicine
  • Xenobiotica
  • KZ-41, a quinic acid derivative, significantly reduces mortality in a murine model of hematopoietic acute radiation syndrome. The purpose of this study was to evaluate the systemic pharmacokinetics, elimination, and oral bioavailability of KZ-41 in rats. Male Sprague-Dawley rats (n = 6 per group) received a single dose (10 mg/kg) of KZ-41 administered either intravenously via the jugular vein or orally via gavage. In vitro stability was determined using both rat liver microsomes and the… CONTINUE READING
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