Preclinical models of stroke in aged animals with or without comorbidities: role of neuroinflammation

@article{Buga2013PreclinicalMO,
  title={Preclinical models of stroke in aged animals with or without comorbidities: role of neuroinflammation},
  author={A.-M. Buga and Mario Di Napoli and Aurel Popa-Wagner},
  journal={Biogerontology},
  year={2013},
  volume={14},
  pages={651-662}
}
Age is the principal nonmodifiable risk factor for stroke. Over the past 10 years, suitable models for stroke in aged rats have been established. At genetic and cellular level there are significant differences in behavioral, cytological and genomics responses to injury in old animals as compared with the young ones. Behaviorally, the aged rats have the capacity to recover after cortical infarcts albeit to a lower extent than the younger counterparts. Similarly, the increased vulnerability of… CONTINUE READING

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