Preclinical evaluation of thermoreversible triamcinolone acetonide hydrogels for drug delivery to the inner ear

@inproceedings{Engleder2014PreclinicalEO,
  title={Preclinical evaluation of thermoreversible triamcinolone acetonide hydrogels for drug delivery to the inner ear},
  author={Elisabeth Engleder and Clemens Honeder and Julia Klobasa and M. Ruzhansky-J. Wirth and Christoph Arnoldner and Franz Gabor},
  booktitle={International journal of pharmaceutics},
  year={2014}
}
Intratympanic glucocorticoid therapy aims to reduce the side effects associated with systemic long-time therapy of inner ear diseases or traumata after cochlear implantation. For that purpose, thermoreversible hydrogels being fluid at room temperature but solid at body temperature are known to be appropriate drug delivery systems. In this work, the two key parameters sol-gel transition time and temperature of Poloxamer 407 (POX 407) based hydrogels containing oto-compatible micronized… CONTINUE READING

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  • AAPS PharmSciTech
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