Preclinical evaluation of sodium cellulose sulfate (Ushercell) as a contraceptive antimicrobial agent.

  title={Preclinical evaluation of sodium cellulose sulfate (Ushercell) as a contraceptive antimicrobial agent.},
  author={Robert A. Anderson and Kenneth A. Feathergill and X Diao and Morris D. Cooper and Risa Kirkpatrick and Betsy C. Herold and Gustavo F. Doncel and Calvin J. Chany and Donald P. Waller and William F. Rencher and Lourens J. D. Zaneveld},
  journal={Journal of andrology},
  volume={23 3},
The spread of sexually transmitted infections (STIs) and limited methods for control of pregnancies presents high risks to the reproductive health of women. Methods controlled by women and directed toward disease prevention and contraception are needed. We report on preclinical studies of the biological properties of sodium cellulose sulfate (Ushercell) currently being developed for use as a topical contraceptive antimicrobial agent. Ushercell was evaluated with tests designed to identify its… 
Biological activity assessment of a novel contraceptive antimicrobial agent.
It is concluded that sulphonated hesperidin can be developed as a potential microbicide for a dual prophylaxis of contraception and transmission of STDs and AIDS.
Original research article Contraceptive efficacy of antimicrobial peptide Nisin: in vitro and in vivo studies
It is suggested that Nisin, with its antibacterial and spermicidal activities, could be developed as a potent vaginal contraceptive for future use in humans.
Evaluation of antimicrobial peptide nisin as a safe vaginal contraceptive agent in rabbits: in vitro and in vivo studies.
It is suggested that nisin with spermicidal and antimicrobial properties could serve as a safe vaginal contraceptive for future therapeutic interventions in STIs.
Enhancement of HIV infection by cellulose sulfate.
It is shown that cellulose sulfate has a biphasic effect on HIV infection in vitro: at high concentrations it inhibits infection but at low concentrations it significantly and reproducibly increases HIV infection.
Formulation, pharmacokinetics and pharmacodynamics of topical microbicides.
  • J. AdamsA. Kashuba
  • Biology, Medicine
    Best practice & research. Clinical obstetrics & gynaecology
  • 2012
Application and removal of polyanionic microbicide compounds enhances subsequent infection by HIV-1
These studies, which demonstrate significant increases in HIV-1 infection subsequent to application and removal of LC and CS, support plausible explanations for the failures of microbicides formulated from these compounds.


Sperm enzyme inhibitors for vaginal and other contraception.
Inhibitors of sperm enzymes whether chemical agents or antibodies could be potent contraceptives whose use is attractive because enzymes are often sperm specific and the inhibitors can be applied locally in the female.
Sulfated polysaccharides inhibit lymphocyte-to-epithelial transmission of human immunodeficiency virus-1.
In the present in vitro study, evidence is presented that a number of sulfated polysaccharides, including carrageenan, dextran sulfate, heparin, fucoidan, and pentosan polysulfate, are capable of blocking infection by mechanisms other than adhesion at concentrations of a thousand times lower than the dosages that are needed to block cell adhesion.
Prophylactic contraceptives for HIV/AIDS.
An overview of current microbicide research is presented and the identification and preclinical development of novel non-detergent spermicidal nucleoside and non-nucleoside inhibitors aimed at decreasing pregnancy and preventing sexual transmission of HIV are reported on.