Preclinical evaluation of novel antibacterial agents by microbiological and molecular techniques

@article{ONeill2004PreclinicalEO,
  title={Preclinical evaluation of novel antibacterial agents by microbiological and molecular techniques},
  author={A. O’Neill and I. Chopra},
  journal={Expert Opinion on Investigational Drugs},
  year={2004},
  volume={13},
  pages={1045 - 1063}
}
  • A. O’Neill, I. Chopra
  • Published 2004
  • Biology, Medicine
  • Expert Opinion on Investigational Drugs
  • The defining property of an antibacterial agent is its ability to selectively interfere with bacterial growth and/or survival. Consequently, a considerable and crucial part of the preclinical evaluation of any novel antibacterial drug involves judging and characterising its effects on bacteria in vitro. These critical stages in drug development are sometimes made to appear somewhat trivial, sandwiched as they are between the highly demanding antibacterial discovery process and the formidable… CONTINUE READING
    84 Citations

    Topics from this paper

    Antibacterial activity and mechanism of action of lipophilic antioxidants.
    • PDF
    Natural Products as a Source for Novel Antibiotics.
    • M. Moloney
    • Biology, Medicine
    • Trends in pharmacological sciences
    • 2016
    • 119
    Identification of a Novel Protein Synthesis Inhibitor Active against Gram‐Positive Bacteria
    • 3
    • PDF
    An Improved Small-Molecule Inhibitor of FtsZ with Superior In Vitro Potency, Drug-Like Properties, and In Vivo Efficacy
    • 59
    • PDF
    XF-73, a novel antistaphylococcal membrane-active agent with rapid bactericidal activity.
    • 64
    • PDF
    A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents.
    • 87
    • PDF
    Challenges of Antibacterial Discovery
    • L. Silver
    • Biology, Medicine
    • Clinical Microbiology Reviews
    • 2011
    • 836
    • PDF
    The Antibiotic Future
    • 5
    • PDF

    References

    SHOWING 1-10 OF 149 REFERENCES
    Screening of natural products for antimicrobial agents
    • L. Silver, K. Bostian
    • Biology, Medicine
    • European Journal of Clinical Microbiology and Infectious Diseases
    • 2005
    • 76
    Discovery and development of new antimicrobial agents.
    • T. Gootz
    • Biology, Medicine
    • Clinical Microbiology Reviews
    • 1990
    • 85
    • PDF
    New (and not so new) antibacterial targets - from where and when will the novel drugs come?
    • S. Projan
    • Biology, Medicine
    • Current opinion in pharmacology
    • 2002
    • 117
    Anti-staphylococcal activity and mode of action of clofazimine.
    • 52
    • PDF
    Novel antibacterials: a genomics approach to drug discovery.
    • 40
    Biochemical and genetic characterization of the action of triclosan on Staphylococcus aureus.
    • 120
    • PDF
    Detection of novel secondary metabolites.
    • 48
    Peptide Deformylase as an Antibacterial Drug Target: Target Validation and Resistance Development
    • 122
    • PDF
    Applications of therapy in animal models to bacterial infection in human disease.
    • 19