Preclinical evaluation of long-acting muscarinic antagonists: comparison of tiotropium and investigational drugs.

@article{Casarosa2009PreclinicalEO,
  title={Preclinical evaluation of long-acting muscarinic antagonists: comparison of tiotropium and investigational drugs.},
  author={Paola Casarosa and Thierry Bouyssou and Sabine Germeyer and Andreas Schnapp and Florian Gantner and Michael Pieper},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2009},
  volume={330 2},
  pages={660-8}
}
Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation caused by persistent inflammatory processes in the airways. An increased cholinergic tone mediates different pathophysiological features of COPD, such as bronchoconstriction and mucus hypersecretion, mostly through activation of the human muscarinic M(3) receptor (hM(3)) subtype. Tiotropium bromide (Spiriva) is a well established muscarinic antagonist in the pharmacological management of COPD with a… CONTINUE READING
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