Preclinical evaluation of differentially targeting dual virotherapy for human solid cancer.

@article{Sakai2010PreclinicalEO,
  title={Preclinical evaluation of differentially targeting dual virotherapy for human solid cancer.},
  author={Ryo Sakai and Shunsuke Kagawa and Yasumoto Yamasaki and Toru Kojima and Futoshi Uno and Yuuri Hashimoto and Yuichi Watanabe and Yasuo Urata and Noriaki Tanaka and Toshiyoshi Fujiwara},
  journal={Molecular cancer therapeutics},
  year={2010},
  volume={9 6},
  pages={1884-93}
}
Multimodal approaches combining drugs that differentially function is the most popular regimen for treating human cancer. Understanding the molecular mechanisms underlying the synergistic, potentiative, and antagonistic effects of drug combinations could facilitate the discovery of novel efficacious combinations. We previously showed that telomerase-specific replication-competent adenovirus (Telomelysin, OBP-301), in which the human telomerase reverse transcriptase promoter controls the… CONTINUE READING