Preclinical evaluation of a new, stabilized neurotensin(8--13) pseudopeptide radiolabeled with (99m)tc.

Abstract

UNLABELLED The rapid degradation of neurotensin (NT) limits its clinical use in cancer imaging and therapy. Thus, a new NT(8--13) pseudopeptide, NT-VIII, was synthesized. Some changes were introduced in the sequence of NT(8--13) to stabilize the molecule against enzymatic degradation: Arg(8) was N-methylated, and Lys and Tle replaced Arg(9) and Ile(12… (More)

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@article{GarcaGarayoa2002PreclinicalEO, title={Preclinical evaluation of a new, stabilized neurotensin(8--13) pseudopeptide radiolabeled with (99m)tc.}, author={Elisa Garc{\'i}a-Garayoa and Peter Blaeuenstein and Matthias Bruehlmeier and Alain Blanc and Koen Iterbeke and Peter Conrath and Dirk A. Tourw{\'e} and Pius August Schubiger}, journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine}, year={2002}, volume={43 3}, pages={374-83} }