Preclinical evaluation of MnDPDP: new paramagnetic hepatobiliary contrast agent for MR imaging.

@article{Elizondo1991PreclinicalEO,
  title={Preclinical evaluation of MnDPDP: new paramagnetic hepatobiliary contrast agent for MR imaging.},
  author={G Elizondo and C J Fretz and David D. Stark and S M Rocklage and Steven C. Quay and Dilip Worah and Y. Ming Tsang and Margaret Chia-Mei Chen and Joseph T. Ferrucci},
  journal={Radiology},
  year={1991},
  volume={178 1},
  pages={73-8}
}
Manganese(II)-N,N'-dipyridoxylethylenediamine-N,N'-diacetate-5,5'-bis (phosphate) (MnDPDP) is a paramagnetic complex designed for use as a hepatobiliary agent. The T1 relaxivity of MnDPDP (2.8 [mmol/L]-1.sec-1 in aqueous solution) was similar to that of gadolinium diethylenetriaminepentaacetic acid (DTPA) (4.5 [mmol/L]-1.sec-1) and gadolinium tetraazocyclodecanetetraacetic acid (DOTA) (3.8 [mmol/L]-1.sec-1). However, in liver tissue the T1 relaxivity of MnDPDP (21.7 [mmol/L]-1.sec-1) was… CONTINUE READING