Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate.

  title={Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate.},
  author={J. Ashok Vardhan Reddy and Ryan Dorton and Elaine Westrick and Alicia Dawson and Terri M Smith and Le-cun Xu and Marilynn Vetzel and Paul J Kleindl and Iontcho R. Vlahov and Christopher P. Leamon},
  journal={Cancer research},
  volume={67 9},
We recently developed a new group of folate-conjugated Vinca alkaloids, one of which, EC145, emerged as a candidate for clinical development. Brief treatment of nude mice bearing approximately 100 mm(3) folate receptor-positive human xenografts led to complete response (CR) in 5/5 mice and cures (i.e., remission without a relapse for >90 days post-tumor implantation) in 4/5 mice. Multiple CRs and cures were also noted when EC145 was used to treat mice initially bearing tumors as large as 750 mm… CONTINUE READING


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