Preclinical development of a neutral, estrogen receptor-targeted, tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivative for imaging of breast and endometrial cancers.

@article{Nayak2008PreclinicalDO,
  title={Preclinical development of a neutral, estrogen receptor-targeted, tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivative for imaging of breast and endometrial cancers.},
  author={T. K. Nayak and Helen J Hathaway and Chinnasamy Ramesh and Jeffrey B. Arterburn and Donghai Dai and Larry A. Sklar and Jeffrey P. Norenberg and Eric R Prossnitz},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2008},
  volume={49 6},
  pages={978-86}
}
UNLABELLED Breast and endometrial cancers are the most common invasive malignancies in women, with more than 217,000 new diagnoses per year in the United States. These cancers are often classified into 2 subtypes based on the expression of the classical estrogen receptor. In this study, we describe a new structural class of neutral tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivatives for potential use in breast and endometrial cancer imaging. METHODS The 99mTc(I)-estradiol-pyridin… CONTINUE READING

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1.5 nM. In vivo studies revealed that receptor - mediated uptake was present in all phases of the estrous cycle in reproductive organs and mammary glands but was highest during the diestrous phase of the estrous cycle .
1.5 nM. In vivo studies revealed that receptor - mediated uptake was present in all phases of the estrous cycle in reproductive organs and mammary glands but was highest during the diestrous phase of the estrous cycle .
1.5 nM. In vivo studies revealed that receptor - mediated uptake was present in all phases of the estrous cycle in reproductive organs and mammary glands but was highest during the diestrous phase of the estrous cycle .
1.5 nM. In vivo studies revealed that receptor - mediated uptake was present in all phases of the estrous cycle in reproductive organs and mammary glands but was highest during the diestrous phase of the estrous cycle .
1.5 nM. In vivo studies revealed that receptor - mediated uptake was present in all phases of the estrous cycle in reproductive organs and mammary glands but was highest during the diestrous phase of the estrous cycle .
1.5 nM. In vivo studies revealed that receptor - mediated uptake was present in all phases of the estrous cycle in reproductive organs and mammary glands but was highest during the diestrous phase of the estrous cycle .
1.5 nM. In vivo studies revealed that receptor - mediated uptake was present in all phases of the estrous cycle in reproductive organs and mammary glands but was highest during the diestrous phase of the estrous cycle .
1.5 nM. In vivo studies revealed that receptor - mediated uptake was present in all phases of the estrous cycle in reproductive organs and mammary glands but was highest during the diestrous phase of the estrous cycle .
1.5 nM. In vivo studies revealed that receptor - mediated uptake was present in all phases of the estrous cycle in reproductive organs and mammary glands but was highest during the diestrous phase of the estrous cycle .
1.5 nM. In vivo studies revealed that receptor - mediated uptake was present in all phases of the estrous cycle in reproductive organs and mammary glands but was highest during the diestrous phase of the estrous cycle .
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