Preclinical development of AMG 139, a human antibody specifically targeting IL-23.

Abstract

BACKGROUND AND PURPOSE AMG 139 is a human anti-IL-23 antibody currently in a phase II trial for treating Crohn's disease. To support its clinical development in humans, in vitro assays and in vivo studies were conducted in cynomolgus monkeys to determine the pharmacology, preclinical characteristics and safety of this monoclonal antibody. EXPERIMENTAL… (More)
DOI: 10.1111/bph.12904

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