Preclinical derivation and imaging of autologously transplanted canine induced pluripotent stem cells.

@article{Lee2011PreclinicalDA,
  title={Preclinical derivation and imaging of autologously transplanted canine induced pluripotent stem cells.},
  author={Andrew Stephen Lee and Dan Xu and Jordan R. Plews and Patricia K. Nguyen and Divya Nag and Jennifer K. Lyons and Leng Han and Shijun Hu and Feng Lan and Junwei Liu and Mei Huang and Kazim H Narsinh and Charles Tyler Long and Patricia Eliza De Almeida and Benjamin L{\'e}vi and Nigel G. Kooreman and Charles D. Bangs and Cholawat Pacharinsak and Fumiaki Ikeno and Alan Yeung and Sanjiv Sam Gambhir and Robert Clayton Robbins and Michael Thornton Longaker and Joseph C Wu},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 37},
  pages={32697-704}
}
Derivation of patient-specific induced pluripotent stem cells (iPSCs) opens a new avenue for future applications of regenerative medicine. However, before iPSCs can be used in a clinical setting, it is critical to validate their in vivo fate following autologous transplantation. Thus far, preclinical studies have been limited to small animals and have yet to be conducted in large animals that are physiologically more similar to humans. In this study, we report the first autologous… CONTINUE READING
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