Preclinical comparison of (111)In-labeled DTPA- or DOTA-bombesin analogs for receptor-targeted scintigraphy and radionuclide therapy.

@article{Breeman2002PreclinicalCO,
  title={Preclinical comparison of (111)In-labeled DTPA- or DOTA-bombesin analogs for receptor-targeted scintigraphy and radionuclide therapy.},
  author={Wouter A. P. Breeman and M. M. Th. de Jong and Jack L. Erion and Joseph E Bugaj and Ananth Srinivasan and Bert F. Bernard and Dik J. Kwekkeboom and Theo J. Visser and Eric P. Krenning},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2002},
  volume={43 12},
  pages={1650-6}
}
UNLABELLED The 14-amino-acid peptide bombesin (BN) has a high affinity for the gastrin-releasing peptide (GRP) receptor that is expressed by a variety of tumors. Recently, high densities of GRP receptors were identified by in vitro receptor autoradiography in human prostate and breast carcinomas using [(125)I-Tyr(4)]BN as radioligand. Radiometal-labeled diethylenetriaminepentaacetic acid (DTPA)-BN derivatives are potentially useful radioligands for receptor-targeted scintigraphy and… CONTINUE READING

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Radiolabelled peptides for oncological diagnosis

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