Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen

@article{McLaughlin2009PreclinicalCO,
  title={Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen},
  author={John McLaughlin and Vadim Markovtsov and Hui Li and Steve Wong and Marina S. Gelman and Yanhong Zhu and Christian Franci and Dr. W. Lang and Erlina S Pali and Joe Lasaga and Caroline Low and Feifei Zhao and Betty Chang and Tarikere L. Gururaja and Weiduan Xu and Muhammad Baluom and David J. Sweeny and David C Carroll and Arvinder S Sran and Sambaiah Thota and Manjeet Parmer and Angela Romane and George R Clemens and Elliott B. Grossbard and Kunbin Qu and Yonchu Jenkins and Taisei Kinoshita and Vanessa C. Taylor and Sacha J. Holland and Ankush Argade and Rajinder Singh and Polly R. Pine and Donald G. Payan and Yasumichi Hitoshi},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2009},
  volume={136},
  pages={99-113}
}
Aurora kinases play a key role in mitotic progression. Over-expression of Aurora kinases is found in several human cancers and correlated with histological malignancy and clinical outcomes. Therefore, Aurora kinase inhibitors should be useful in the treatment of cancers. Cell-based screening methods have an advantage over biochemical approaches because hits can be optimized to inhibit targets in the proper intracellular context. We developed a novel Aurora kinase inhibitor R763/AS703569 using… CONTINUE READING
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