Preclinical antitumour activity and animal toxicology studies of rhizoxin, a novel tubulin-interacting agent.

@article{Hendriks1992PreclinicalAA,
  title={Preclinical antitumour activity and animal toxicology studies of rhizoxin, a novel tubulin-interacting agent.},
  author={Hans R. Hendriks and Jacqueline Plowman and Dietmar P. Berger and Kenneth D. Paull and Heinz Herbert Fiebig and Oystein Fodstad and H C Dreef-van der Meulen and Roland E. C. Henrar and Herbert M. Pinedo and Gilberto Schwartsmann},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={1992},
  volume={3 9},
  pages={755-63}
}
Rhizoxin is a 16-membered antifungal macrocyclic lactone isolated from the plant pathogenic fungus Rhizopus chinensis. The compound binds to tubulin, preventing microtubule formation, and inhibiting mitosis. It possesses antitumour activity in vivo against various preclinical murine models, both leukaemias and solid tumours model, as well as in vincristine- and doxorubicin-resistant leukaemia lines. In the present study, cytotoxic activity was observed in human tumour cell lines in vitro at… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…