Preclinical antitumor activity of penclomedine in mice: cross-resistance, schedule dependence, and oral activity against tumor xenografts in brain.

@article{Harrison1991PreclinicalAA,
  title={Preclinical antitumor activity of penclomedine in mice: cross-resistance, schedule dependence, and oral activity against tumor xenografts in brain.},
  author={Steadman D. Harrison and Jacqueline Plowman and Donald J. Dykes and William R. Waud and Daniel P. Griswold},
  journal={Cancer research},
  year={1991},
  volume={51 8},
  pages={1979-83}
}
Penclomedine is 3,5-dichloro-2,4-dimethoxy-6-(trichloromethyl)pyridine (NSC 338720), an alpha-picoline derivative with p.o. antitumor activity in preclinical leukemia and solid tumor models. Described here are an in vivo cross-resistance profile of penclomedine, treatment schedule dependence studies, and studies exploring the effects of p.o. drug on human tumors xenografted into mouse brain. The latter studies exploited the apparent facile distribution of penclomedine to the central nervous… CONTINUE READING

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Murine and human in vivo penclomedine metabolism.

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