Corpus ID: 53913533

Preclinical antitumor activity of benzopyranones

  title={Preclinical antitumor activity of benzopyranones},
  author={Rama Krishna Narla and Alice Collette and Bernd Stein and David A. Giegel and Garrick K. Packard and Glenn C Friedman and Heather K. Raymon and Jim Gamez and Jonathan Wright and Kimberly Elizabeth Fultz and Michael Boluro-Ajayi and Michael A. Shirley and Patrick Papa and Paul E. Erdman and Seema Pai and Stephen T. Sakata},
  journal={Cancer Research},
5891 Agents with selective estrogen receptor modulatory (SERM) activities have been widely used in the treatment and prevention of cancers such as breast cancer and endometrial carcinoma that express estrogen receptors. Furthermore, SERMs (e.g., Tamoxifen) also have been shown to have anticancer activity in cancers that do not express estrogen receptors, suggesting an estrogen receptor-independent antitumor mechanism for the agents. CC-8490 is a novel benzopyranone that has potent SERM activity… Expand