Preclinical and Clinical Investigation of Drugs II. Antitussive Drugs

@article{Salem1974PreclinicalAC,
  title={Preclinical and Clinical Investigation of Drugs II. Antitussive Drugs},
  author={H. Salem and D. Aviado},
  journal={Therapeutic Innovation & Regulatory Science},
  year={1974},
  volume={8},
  pages={111 - 143}
}
Interest in antitussive drugs continues to grow, yet the fundamental concept of the mode of action of these drugs remains essentially unchanged. For example, codeine, the prototype of centrally-acting antitussives, suppresses the cough reflex by depressing the cough center in the medulla. Numerous other drugs have been introduced as clinically useful antitussives, almost all of which have a mode of action similar to that of codeine. A review of the literature on antitussive drugs has revealed a… Expand
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