Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder

@inproceedings{Behr2012PreclinicalAC,
  title={Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder},
  author={Guilherme Ant{\^o}nio Behr and Jos{\'e} Cl{\'a}udio Fonseca Moreira and Benicio N. Frey},
  booktitle={Oxidative medicine and cellular longevity},
  year={2012}
}
Major depressive disorder (MDD) is a common mental disorder associated with a significant negative impact on quality of life, morbidity/mortality, and cognitive function. Individuals who suffer with MDD display lower serum/plasmatic total antioxidant potentials and reduced brain GSH levels. Also, F2-isoprostanes circulatory levels are increased in MDD subjects and are correlated with the severity of depressive symptoms. Urinary excretion of 8-OHdG seems to be higher in patients with MDD… CONTINUE READING
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