Preclinical and Clinical Evidence for Disappearance of Long-Circulating Characteristics of Polyethylene Glycol Liposomes at Low Lipid Dose 1


This study describes the effect of the lipid dose of Tcpolyethylene glycol (PEG) liposomes in the low-dose range (0.02–1.0 mmol/kg) on the pharmacokinetics and biodistribution in rats, rabbits, and humans. The biodistribution and pharmacokinetics of Tc-PEG liposomes at various dose levels were studied in rats and rabbits with a focal Escherichia coli… (More)

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