Preclinical and Clinical Evidence for Disappearance of Long-Circulating Characteristics of Polyethylene Glycol Liposomes at Low Lipid Dose 1

Abstract

This study describes the effect of the lipid dose of Tcpolyethylene glycol (PEG) liposomes in the low-dose range (0.02–1.0 mmol/kg) on the pharmacokinetics and biodistribution in rats, rabbits, and humans. The biodistribution and pharmacokinetics of Tc-PEG liposomes at various dose levels were studied in rats and rabbits with a focal Escherichia coli… (More)

5 Figures and Tables

Topics

  • Presentations referencing similar topics