Preclinical activity profile of α-lactoalbumin, a whey protein rich in tryptophan, in rodent models of seizures and epilepsy.

@article{Citraro2011PreclinicalAP,
  title={Preclinical activity profile of α-lactoalbumin, a whey protein rich in tryptophan, in rodent models of seizures and epilepsy.},
  author={R. Citraro and Francesca Scicchitano and Salvatore De Fazio and Riccardo Raggio and Paolo Mainardi and Emilio Perucca and Giovambattista De Sarro and Emilio Russo},
  journal={Epilepsy research},
  year={2011},
  volume={95 1-2},
  pages={60-9}
}
PURPOSE To evaluate the potential anticonvulsant activity of α-lactalbumin (ALAC), a whey protein rich in tryptophan (TRP) relative to other large neutral amino acids (LNAAs), in rodent models of seizures and epilepsy. METHODS The effects of ALAC administered per os were evaluated by standard protocols against audiogenic seizures in Genetic Epilepsy Prone Rats (GEPR-9 rats), maximal electroshock (MES)-induced seizures in rats, pilocarpine-induced seizures in mice, spontaneous chronic seizures… CONTINUE READING
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