Preclinical Testing of a Vaccine Candidate against Tularemia

  title={Preclinical Testing of a Vaccine Candidate against Tularemia},
  author={Ragavan Varadharajan Suresh and Zhuo Ma and Raju Sunagar and Vivek Bhatty and Sukalyani Banik and Sally V. Catlett and Edmund Joseph Gosselin and Meenakshi Malik and Chandra Shekhar Bakshi},
  booktitle={PloS one},
Tularemia is caused by a gram-negative, intracellular bacterial pathogen, Francisella tularensis (Ft). The history weaponization of Ft in the past has elevated concerns that it could be used as a bioweapon or an agent of bioterrorism. Since the discovery of Ft, three broad approaches adopted for tularemia vaccine development have included inactivated, live attenuated, or subunit vaccines. Shortcomings in each of these approaches have hampered the development of a suitable vaccine for prevention… CONTINUE READING
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