Preclinical Safety Assessment of the 5-HT2A Receptor Agonist PET Radioligand [11C]Cimbi-36

@article{Ettrup2012PreclinicalSA,
  title={Preclinical Safety Assessment of the 5-HT2A Receptor Agonist PET Radioligand [11C]Cimbi-36},
  author={A. Ettrup and S. Holm and M. Hansen and M. Wasim and M. A. Santini and M. Palner and J. Madsen and C. Svarer and J. Kristensen and G. Knudsen},
  journal={Molecular Imaging and Biology},
  year={2012},
  volume={15},
  pages={376-383}
}
  • A. Ettrup, S. Holm, +7 authors G. Knudsen
  • Published 2012
  • Medicine
  • Molecular Imaging and Biology
  • Purpose[11C]Cimbi-36 was recently developed as an agonist radioligand for brain imaging of serotonin 2A receptors (5-HT2A) with positron emission tomography (PET). This may be used to quantify the high-affinity state of 5-HT2A receptors and may have the potential to quantify changes in cerebral 5-HT levels in vivo. We here investigated safety aspects related to clinical use of [11C]Cimbi-36, including radiation dosimetry and in vivo pharmacology.Procedures[11C]Cimbi-36 was injected in rats or… CONTINUE READING
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