Preclinical Research into Basic Mechanisms of Radiation-Induced Heart Disease

  title={Preclinical Research into Basic Mechanisms of Radiation-Induced Heart Disease},
  author={Marjan Boerma and Martin Hauer-Jensen},
  booktitle={Cardiology research and practice},
Radiation-induced heart disease (RIHD) is a potentially severe side effect of radiotherapy of thoracic and chest wall tumors if all or part of the heart was included in the radiation field. RIHD presents clinically several years after irradiation and manifestations include accelerated atherosclerosis, pericardial and myocardial fibrosis, conduction abnormalities, and injury to cardiac valves. There is no method to prevent or reverse these injuries when the heart is exposed to ionizing radiation… CONTINUE READING


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