Preclinical Evaluation of Safety of Fucoidan Extracts From Undaria pinnatifida and Fucus vesiculosus for Use in Cancer Treatment

@inproceedings{Mathew2017PreclinicalEO,
  title={Preclinical Evaluation of Safety of Fucoidan Extracts From Undaria pinnatifida and Fucus vesiculosus for Use in Cancer Treatment},
  author={Lata Mathew and Maryam N. Burney and Anjali Gaikwad and Pranavand Nyshadham and Elizabeth K. Nugent and Anneliese O. Gonzalez and Judith A. Smith},
  booktitle={Integrative cancer therapies},
  year={2017}
}
OBJECTIVES To evaluate potential hepatic metabolism-mediated drug interactions with fucoidan from Undaria pinnatifida (UPF) or Fucus vesiculosus (FVF) and potential growth inhibition activity with either fucoidan alone or with chemotherapy. In vivo studies were done to confirm safety and investigate fucoidan-mediated immune modulation. METHODS Cytochrome P450 (CYP450) 3A4, 2C8, 2C9, and 2D6 inhibition experiments were conducted in vitro followed by an ex vivo human hepatocytes model to… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 24 REFERENCES

A quantitative method to detect fucoidan in human plasma using a novel antibody.

  • Methods and findings in experimental and clinical pharmacology
  • 2005
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

and Drug Administration

US Foo
  • Guidance for industry: bioanalytical method assay validation, May 2001 http:// www.fda.gov/downloads/Drugs/Guidances/ucm070107.pdf. Published May 2001. Accessed February 2,
  • 2016
VIEW 1 EXCERPT

Anticancer effects of different seaweads on human colon and breast cancer cell lines

G Moussavou, DH Kwak, BW Obiang-Obonou
  • Mar Drugs
  • 2014
VIEW 1 EXCERPT

Similar Papers

Loading similar papers…