Preclinical Enantioselective Pharmacology of (R)‐ and (S)‐ Ketorolac

@article{Handley1998PreclinicalEP,
  title={Preclinical Enantioselective Pharmacology of (R)‐ and (S)‐ Ketorolac},
  author={D. Handley and P. Cervoni and J. McCray and J. Mccullough},
  journal={The Journal of Clinical Pharmacology},
  year={1998},
  volume={38}
}
Many of the nonsteroidal anti‐inflammatory drugs (NSAIDs) are marketed as racemic mixtures, composed of (R)‐ and (S)‐ enantiomers. Racemic NSAIDs are potent cyclooxygenase (COX) inhibitors only through the action of the (S)‐ enantiomers, as the (R)‐ enantiomers do not exhibit COX inhibition. However, the (R)‐ enantiomer of ketoprofen exhibits potent analgesic activity and minimal ulcerogenic potential. To extend these observations, we examined the (R)‐ and (S)‐ enantiomers of RS‐ketorolac. (S… Expand

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