Preclinical Efficacy of Melatonin to Reduce Methotrexate-Induced Oxidative Stress and Small Intestinal Damage in Rats

@article{Kolli2012PreclinicalEO,
  title={Preclinical Efficacy of Melatonin to Reduce Methotrexate-Induced Oxidative Stress and Small Intestinal Damage in Rats},
  author={Viswa Kalyan Kolli and Premila Abraham and Bina Isaac and Narayanan Kasthuri},
  journal={Digestive Diseases and Sciences},
  year={2012},
  volume={58},
  pages={959-969}
}
BackgroundMethotrexate is widely used as a chemotherapeutic agent for leukemia and other malignancies. The efficacy of this drug is often limited by mucositis and intestinal injury, which are the major causes of morbidity in children and adults.AimThe present study investigates whether melatonin, a powerful antioxidant, could have a protective effect.MethodRats were pretreated with melatonin (20 and 40 mg/kg body weight) daily 1 h before methotrexate (7 mg/kg body weight) administration for… Expand
View on Springer
ncbi.nlm.nih.gov
36 Citations
Background Citations
9
Results Citations
2

36 Citations

Citation Type

Citation Type

Pretreatment with melatonin protects against cyclophosphamide‐induced oxidative stress and renal damage in mice
TLDR
The results revealed that MEL might be useful for prevention of the nephrotoxicity induced by CP through ameliorative effects on biochemical indices and oxidative stress parameters. Expand
Rutin attenuates intestinal toxicity induced by Methotrexate linked with anti-oxidative and anti-inflammatory effects
TLDR
The positive modulation of MTX toxicity could be attributed to the free radical scavenging and anti-inflammatory (dual inhibition of arachidonic acid pathways) potential of rutin. Expand
Protective effect of melatonin against methotrexate-induced testicular damage in the rat model: An experimental study
TLDR
Melatonin improves the epididymal sperm concentration by decreasing the expression of caspase-3 and increasing that of tyrosine-phosphorylated proteins in MTX-treated testes, indicating its protective effect against testicular damage induced by MTX. Expand
Melatonin-lycopene combination improves methotrexate-induced liver toxicity in rats via anti-inflammatory effect
TLDR
The LYC-MLT combination improved the acute toxic effects of MTX on the liver, and improved both liver function and the histopathology level, but oxidative stress parameters such as TOS and OSI did not change in MIT. Expand
Protective effect of resveratrol against methotrexate-induced oxidative stress in the small intestinal tissues of rats.
TLDR
Resveratrol and famotidine were found to significantly prevent elevation of the MDA, 8-OH/Gua and MPO parameters with MTX and decrease of the levels of tGSH in the duodenal and jejunal tissues. Expand
Mitochondrial dysfunction and respiratory chain defects in a rodent model of methotrexate-induced enteritis
TLDR
The results of the present study suggest that MTX-induced damage to enterocyte mitochondria may play a critical role in enteritis, and methotrexate-induced alteration in mitochondrial structure may cause its dysfunction and decreases the activities of the electron chain complexes. Expand
Melatonin protects against cisplatin-induced ovarian damage in mice via the MT1 receptor and antioxidant activity†
TLDR
Melatonin attenuated cisplatin-induced ovarian damage in mice, and the MT1 receptor could be used as a promising therapeutic target to the development of novel agents for preserving ovarian function during chemotherapy. Expand
Lutein Protects against Methotrexate-Induced and Reactive Oxygen Species-Mediated Apoptotic Cell Injury of IEC-6 Cells
TLDR
The MTX-induced apoptosis of IEC-6 cells was shown to be repressed by the pre-treatment of lutein, which may represent a promising adjunct to conventional chemotherapy for preventing intestinal damages. Expand
Influence of subacute melatonin treatment on antioxidant factors in the liver of female rats
TLDR
Melatonin treatment causes changes in female rats liver functions and further investigations are necessary to examine the full impact of melatonin supplementation with regards to route of administration, dose as well as the exposure period. Expand
Role of IL-6/STAT3 pathway in mediating the protective effect of agomelatine against methotrexate-induced lung/intestinal tissues damage in rats.
TLDR
By reducing oxidative stress, inflammatory processes, and modulating the IL-6/STAT3 pathway, Ago has potent ameliorative effects against MTX-induced lung/intestinal toxicities. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 62 REFERENCES
Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats
TLDR
It is suggested that oxidative stress plays an important role in the MTX-induced small intestinal damage, especially neutrophil infiltration, and the modulation of oxidative stress would be useful in reducing intestinal damage in MTX treatment. Expand
Melatonin prevents methotrexate‐induced hepatorenal oxidative injury in rats
TLDR
The present study suggests that melatonin may be of therapeutic benefit when used with MTX and elucidates the role of free radicals in MTX‐induced toxicity and the protection by melatonin. Expand
L-Carnitine ameliorates methotrexate-induced oxidative organ injury and inhibits leukocyte death
TLDR
The results suggest that L-Car, possibly via its free radical scavenging and antioxidant properties, ameliorates MTX-induced oxidative organ injury and inhibits leukocyte apoptosis and may be promising in alleviating the systemic side-effects of chemotherapeutics. Expand
Beta-glucan ameliorates methotrexate-induced oxidative organ injury via its antioxidant and immunomodulatory effects.
TLDR
The findings of the present study suggest that beta-glucan, through its antioxidant and immunoregulatory effects, may be of therapeutic value in alleviating the leukocyte apoptosis, oxidative tissue injury and thereby the intestinal and hepatorenal side effects of methotrexate treatment. Expand
Effects of N-acetylcysteine on methotrexate-induced small intestinal damage in rats.
TLDR
Administration of N-acetylcysteine provides protection against the MTX-induced damage to small intestinal epithelium in rats, and this protective effect of NAC may have clinical applications in chemotherapy. Expand
Protective role of lipoic acid on methotrexate induced intestinal damage in rabbit model
  • M. Somi, B. Hajipour, +4 authors A. Vatankhah
  • Physics, Medicine
  • Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
  • 2011
TLDR
It is suggested that lipoic acid may have a protective role in the MTX-induced oxidative injury, and co-administration of LA with MTX is associated with reduction in oxidative injury and tissue damage in the intestine. Expand
Oxidative stress and enhanced paracellular permeability in the small intestine of methotrexate-treated rats
TLDR
NAC protected the small intestine of rats from MTX-induced change in paracellular permeability, suggesting that ROS played an important role in the enhanced parace cellular permeability. Expand
Effect of aged garlic extract against methotrexate‐induced damage to the small intestine in rats
TLDR
It is suggested that AGE may protect the small intestine of rats from MTX‐induced damage, and substantiated the thought that the protective effect of AGE is derived from the manner in which it interacts with crypt cells. Expand
Protective effect of melatonin on indomethacin‐induced gastric injury in rats
TLDR
The results suggest that the protection afforded by the pineal hormone against indomethacin‐induced gastric injury may be, in addition to other possible mechanisms, to its radical scavenging activity. Expand
Melatonin ameliorates ionizing radiation-induced oxidative organ damage in rats.
TLDR
The increase in MDA levels and MPO activity and the concomitant decrease in GSH levels demonstrate the role of oxidative mechanisms in irradiation-induced tissue damage, and melatonin, by its free radical scavenging and antioxidant properties, ameliorates irradiated organ injury. Expand
...
1
2
3
4
5
...