Preclinical Efficacy of Melatonin to Reduce Methotrexate-Induced Oxidative Stress and Small Intestinal Damage in Rats

@article{Kolli2012PreclinicalEO,
  title={Preclinical Efficacy of Melatonin to Reduce Methotrexate-Induced Oxidative Stress and Small Intestinal Damage in Rats},
  author={Viswa Kalyan Kolli and Premila Abraham and Bina Isaac and Narayanan Kasthuri},
  journal={Digestive Diseases and Sciences},
  year={2012},
  volume={58},
  pages={959-969}
}
BackgroundMethotrexate is widely used as a chemotherapeutic agent for leukemia and other malignancies. The efficacy of this drug is often limited by mucositis and intestinal injury, which are the major causes of morbidity in children and adults.AimThe present study investigates whether melatonin, a powerful antioxidant, could have a protective effect.MethodRats were pretreated with melatonin (20 and 40 mg/kg body weight) daily 1 h before methotrexate (7 mg/kg body weight) administration for… Expand
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