Preclinical Development Sensitivity ofSelectedHumanTumorModels toPF-04217903 , a Novel Selective c-Met Kinase Inhibitor

The c-Met pathway has been implicated in a variety of human cancers for its critical role in tumor growth, invasion, andmetastasis. PF-04217903 is a novelATP-competitive small-molecule inhibitor of c-Met kinase. PF04217903 showed more than 1,000-fold selectivity for c-Met compared with more than 150 kinases, making it one of the most selective c-Met… (More)