Preclinical Analgesic and Safety Evaluation of the GalR2-preferring Analog, NAX 810-2

@article{Metcalf2017PreclinicalAA,
  title={Preclinical Analgesic and Safety Evaluation of the GalR2-preferring Analog, NAX 810-2},
  author={Cameron S. Metcalf and Misty D. Smith and Brian D. Klein and Daniel R. McDougle and Liuyin Zhang and Grzegorz Bulaj},
  journal={Neurochemical Research},
  year={2017},
  volume={42},
  pages={1983-1994}
}
The potential clinical utility of galanin peptidic analogs has been hindered by poor metabolic stability, lack of brain penetration, and hyperglycemia. In addition to possessing potent anticonvulsant efficacy, galanin analogs are analgesic in various assays. The purpose of these studies was to evaluate the lead galanin receptor type 2 (GalR2)-preferring analog, NAX 810-2, in various pain assays, as well as determine any potential for insulin inhibition, growth hormone stimulation, and cognitive… 

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