Preclinical (premotor) Parkinson’s disease

  title={Preclinical (premotor) Parkinson’s disease},
  author={Erik Ch. Wolters and Chantal Francot and P. L. M. Bergmans and Ania Winogrodzka and Jan Booij and Henk W. Berendse and Johannes C. Stoof},
  journal={Journal of Neurology},
Parkinson’s disease (PD) is an idiopathic disease caused by necrosis and apoptosis of dopaminergic cells in the brainstem, which are probably induced by oxidative stress. Current therapeutic strategies comprise symptomatic and restorative treatment. Neuroprotective treatment, however, is close to becoming reality. As neuroprotective therapy may be of particular benefit to the preclinical and/or very early PD patients, identifying patients in the early stages of the disease is a priority. Both… CONTINUE READING
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Reduced olfactory dysfunction in Parkinson ’ s disease

  • G Tissingh, P Bergmans, A Winogrodzka, B Drukarch, JC Stoof, Wolters ECh
  • Mov Disord
  • 1999

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