Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

  title={Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile},
  author={Charlie G. Buffie and Vanni Bucci and Richard R. Stein and Peter T McKenney and Lilan Ling and Asia C Gobourne and Daniel No and Hui Liu and Melissa A. Kinnebrew and Agnes J. Viale and Eric R Littmann and Marcel R. M. van den Brink and Robert R Jenq and Ying Taur and Chris Sander and Justin R. Cross and Nora C. Toussaint and Jo{\~a}o B. Xavier and Eric G. Pamer},
The gastrointestinal tracts of mammals are colonized by hundreds of microbial species that contribute to health, including colonization resistance against intestinal pathogens. Many antibiotics destroy intestinal microbial communities and increase susceptibility to intestinal pathogens. Among these, Clostridium difficile, a major cause of antibiotic-induced diarrhoea, greatly increases morbidity and mortality in hospitalized patients. Which intestinal bacteria provide resistance to C. difficile… CONTINUE READING
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