Precision high-throughput proton NMR spectroscopy of human urine, serum, and plasma for large-scale metabolic phenotyping.

@article{Dona2014PrecisionHP,
  title={Precision high-throughput proton NMR spectroscopy of human urine, serum, and plasma for large-scale metabolic phenotyping.},
  author={Anthony Dona and Beatriz Jim{\'e}nez and Hartmut Schaefer and Eberhard Humpfer and Manfred Spraul and Matthew Lewis and Jake Thomas Midwinter Pearce and Elaine Holmes and John C. Lindon and Jeremy K. Nicholson},
  journal={Analytical chemistry},
  year={2014},
  volume={86 19},
  pages={9887-94}
}
Proton nuclear magnetic resonance (NMR)-based metabolic phenotyping of urine and blood plasma/serum samples provides important prognostic and diagnostic information and permits monitoring of disease progression in an objective manner. Much effort has been made in recent years to develop NMR instrumentation and technology to allow the acquisition of data in an effective, reproducible, and high-throughput approach that allows the study of general population samples from epidemiological… CONTINUE READING

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