Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function

@inproceedings{Burkard2017PrecisionEF,
  title={Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function},
  author={Christine Burkard and Simon G Lillico and Elizabeth Reid and Ben Jackson and Alan John Mileham and Tahar Ait-Ali and Christopher Bruce Alexander Whitelaw and Alan L. Archibald},
  booktitle={PLoS pathogens},
  year={2017}
}
Porcine Reproductive and Respiratory Syndrome (PRRS) is a panzootic infectious disease of pigs, causing major economic losses to the world-wide pig industry. PRRS manifests differently in pigs of all ages but primarily causes late-term abortions and stillbirths in sows and respiratory disease in piglets. The causative agent of the disease is the positive-strand RNA PRRS virus (PRRSV). PRRSV has a narrow host cell tropism, limited to cells of the monocyte/macrophage lineage. CD163 has been… CONTINUE READING

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