Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits


T cells can be re-directed to kill cancer cells using chimeric antigen receptors (CARs) or T cell receptors (TCRs). This approach, however, is constrained by the rarity of tumor-specific single antigens. Targeting antigens also found on bystander tissues can cause life-threatening adverse effects. A powerful way to enhance ON-target activity of therapeutic… (More)
DOI: 10.1016/j.cell.2016.01.011


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