Precisely defining high-risk operable head and neck tumors based on RTOG #85-03 and #88-24: targets for postoperative radiochemotherapy?

@article{Cooper1998PreciselyDH,
  title={Precisely defining high-risk operable head and neck tumors based on RTOG #85-03 and #88-24: targets for postoperative radiochemotherapy?},
  author={Jay Scott Cooper and Thomas F. Pajak and Arlene A. Forastiere and J. Kenneth Jacobs and Karen K. Fu and Kie Kian Ang and George Ernest Laramore and Muhyi al-Sarraf},
  journal={Head & neck},
  year={1998},
  volume={20 7},
  pages={
          588-94
        }
}
BACKGROUND Local-regional recurrence of disease remains the major obstacle to cure of advanced head and neck cancers. METHODS This investigation reviewed data derived from Radiation Therapy Oncology Group (RTOG) protocols #85-03 and #88-24 to identify characteristics of tumors that predicted local-regional recurrence of disease following surgery and postoperative radiotherapy (RT). RESULTS The presence of tumor in two or more lymph nodes, and/or extracapsular spread of nodal disease, and/or… CONTINUE READING
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