Precise nucleosome positioning and the TATA box dictate requirements for the histone H4 tail and the bromodomain factor Bdf1.

@article{MartinezCampa2004PreciseNP,
  title={Precise nucleosome positioning and the TATA box dictate requirements for the histone H4 tail and the bromodomain factor Bdf1.},
  author={Carlos Martinez-Campa and Panagiotis K Politis and Jean-Luc Moreau and Nick A Kent and Jane Goodall and Jane Mellor and C. R. Goding},
  journal={Molecular cell},
  year={2004},
  volume={15 1},
  pages={69-81}
}
Acetylation of histone tails plays a key role in chromatin dynamics and is associated with the potential for gene expression. We show here that a 2-3 bp mispositioning of the nucleosome covering the TATA box at PHO5 induces a dependency on the acetylatable lysine residues of the histone H4 N-terminal region and on the TFIID-associated bromodomain factor Bdf1. This dependency arises either through fusion of the PHO5 promoter to a lacZ reporter or by mutation of the TATA box in the natural gene… CONTINUE READING

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