Precise estimates of mutation rate and spectrum in yeast.

@article{Zhu2014PreciseEO,
  title={Precise estimates of mutation rate and spectrum in yeast.},
  author={Yuan O Zhu and Mark L Siegal and David W Hall and Dmitri A. Petrov},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 22},
  pages={
          E2310-8
        }
}
Mutation is the ultimate source of genetic variation. The most direct and unbiased method of studying spontaneous mutations is via mutation accumulation (MA) lines. Until recently, MA experiments were limited by the cost of sequencing and thus provided us with small numbers of mutational events and therefore imprecise estimates of rates and patterns of mutation. We used whole-genome sequencing to identify nearly 1,000 spontaneous mutation events accumulated over ∼311,000 generations in 145… CONTINUE READING

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A genome-wide view of the spectrum of spontaneous mutations in yeast

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