Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers.

@article{Gu2008PreciseEO,
  title={Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers.},
  author={Frank X Gu and Liangfang Zhang and Benjamin A. Teply and Nina Mann and Andrew Z. Wang and Aleksandar F. Radovic-Moreno and Robert S Langer and Omid C Farokhzad},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 7},
  pages={2586-91}
}
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained elusive. A central challenge has been defining the optimal interplay of parameters that confer molecular targeting, immune evasion, and drug release to overcome the physiological barriers… CONTINUE READING
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