Precise control of PLG microsphere size provides enhanced control of drug release rate.

  title={Precise control of PLG microsphere size provides enhanced control of drug release rate.},
  author={Cory J Berkland and Martin O King and Amanda Julie Cox and Kyekyoon Kevin Kim and Daniel W Pack},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={82 1},
An important limitation in the development of biodegradable polymer microspheres for controlled-release drug delivery applications has been the difficulty of specifically designing systems exhibiting precisely controlled release rates. Because microparticle size is a primary determinant of drug release, we developed a methodology for controlling release kinetics employing monodisperse poly(D,L-lactide-co-glycolide) (PLG) microspheres. We fabricated 20-, 40- and 65-microm diameter rhodamine… CONTINUE READING
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